Sex-specific alterations in blood-borne factors in physically inactive individuals are detrimental to endothelial cell functions.

ABSTRACT: Mechanisms underlying the protective effects of both habitual endurance exercise and the female sex on vascular function are incompletely understood. Blood-borne circulating factors, such as circulating microRNAs (ci-miRs), may partially explain these effects. Blood samples were obtained from young, healthy men and women who either habitually performed endurance exercise (endurance trained) or were relatively inactive (sedentary). Women were tested during the early follicular phase of the menstrual cycle or the placebo pill phase of oral contraceptive to control for estrogen. Cultured human umbilical vein endothelial cells (HUVECs) were exposed to participants' serum in migration, proliferation, and reactive oxygen species (ROS) assays. Real-time quantitative polymerase chain reaction was

SUBMITTER: Sapp RM 

PROVIDER: S-EPMC7654692 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature