Early changes in immune cell metabolism and function are a hallmark of sleeve gastrectomy: a prospective human study.

ABSTRACT:

Objective

To characterize longitudinal changes in blood biomarkers, leukocyte composition, and gene expression following laparoscopic sleeve gastrectomy (LSG).

Background

LSG is an effective treatment for obesity, leading to sustainable weight loss and improvements in obesity-related co-morbidities and inflammatory profiles. However, the effects of LSG on immune function and metabolism remain uncertain.

Methods

Prospective data was collected from 23 enrolled human subjects from a single institution. Parameters of weight, co-morbidities, and trends in blood biomarkers and leukocyte subsets were observed from pre-operative baseline to one year in three-month follow-up intervals. RNA-sequencing was performed on pairs of whole blood samples from the first six subjects of

SUBMITTER: Lo T 

PROVIDER: S-EPMC7654921 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature