Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study.

ABSTRACT:

Aims

Aortic valve stenosis is commonly considered a degenerative disorder with no recommended preventive intervention, with only valve replacement surgery or catheter intervention as treatment options. We sought to assess the causal association between exposure to lipid levels and risk of aortic stenosis.

Methods and results

Causality of association was assessed using two-sample Mendelian randomization framework through different statistical methods. We retrieved summary estimations of 157 genetic variants that have been shown to be associated with plasma lipid levels in the Global Lipids Genetics Consortium that included 188 577 participants, mostly European ancestry, and genetic association with aortic stenosis as the main outcome from a total of 432 173 participants in th

SUBMITTER: Nazarzadeh M 

PROVIDER: S-EPMC7654932 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature