Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats.

ABSTRACT: The blood-brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently investigated concept for brain drug delivery. However, despite the body of evidence for IN drug delivery in literature over the last decades, reproducibility and interpretation of animal data remain challenging. The objective of this project was to assess the feasibility and value of a standardized IN screening model in rats for the evaluation of direct brain delivery. A chemically diverse set of commercial and internal small molecules were tested in the in vivo model with different doses and/or formulations. Data were analyzed using different ways of ratio calculations: blood concent

SUBMITTER: Dhuyvetter D 

PROVIDER: S-EPMC7655051 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature