Sex disparities in presentation and prognosis of 1110 patients with hepatocellular carcinoma.

ABSTRACT:

Background

Although sex disparities in hepatocellular carcinoma (HCC) incidence have been well described, there are limited data examining sex disparities in HCC prognosis.

Aim

To characterise sex differences in HCC presentation and prognosis.

Methods

We performed a retrospective study of consecutive patients (n = 1110, 23.5% women) diagnosed with HCC between 2008 and 2017 at two US health systems. We used Cox proportional hazard and multivariable logistic regression models to identify factors associated with overall survival, early tumour detection and response to HCC treatment (per the modified Response Evaluation Criteria in Solid Tumors [mRECIST] criteria).

Results

Women were older at HCC diagnosis (mean 62.5 vs 59.2 years, P < 0.001) and had a higher propo

SUBMITTER: Rich NE 

PROVIDER: S-EPMC7655123 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature