SMARCD3 is a potential prognostic marker and therapeutic target in CAFs.

ABSTRACT:

Objective

Screening for novel prognostic biomarkers and potential therapeutic targets from colorectal cancer microenvironment.

Results

372 genes were overexpressed in colorectal cancer microenvironment, five of which that had the most prognostic powers were enriched in Epithelial-Mesenchymal Transition and cell cycle pathways. For the first time, we showed that SMARCD3 was mainly expressed in CAFs and could be a novel prognostic marker and potential therapeutic target. Function analyses indicated that MSARCD3 might promote CAFs activation and colorectal cancer metastasis through SMARCD3-WNT5A/TGF-β-MAPK14-SMARCD3 positive feedback loop. Signaling map of SMARCD3 was constructed and several potential drugs that could regulate SMARCD3 were also presented.

Conclusions

SMA

SUBMITTER: Jiang M 

PROVIDER: S-EPMC7655158 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature