Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma.

ABSTRACT: GTPase of immunity-associated proteins (GIMAPs) are frequently prescribed as important components of immune regulation complexes, which were known to play key roles in lung adenocarcinoma. However, little is known about the function of distinct GIMAPs in lung adenocarcinoma. To address this issue, this study investigated the biological function and pathway of GIMAPs in lung adenocarcinoma using multiple public databases. Absent expression of GIMAPs was found in lung adenocarcinoma at mRNA and protein levels. While a purity-corrected value uncovered that all GIMAPs were positively associated with the immune infiltration of lung adenocarcinoma. Furthermore, the expressions of GIMAPs were considered to be negatively associated with clinical cancer stages, patient's gender and pathological tum

SUBMITTER: Deng S 

PROVIDER: S-EPMC7655191 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature