Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition.

ABSTRACT: The developmental origins of health and disease concept links adult diseases with early-life exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition may lead to an increased incidence of type 2 diabetes, obesity, and cardiovascular diseases. Maternal malnutrition (MM) has also been associated with prostate carcinogenesis. However, the molecular mechanisms associated with this condition remain poorly understood. Using a proteomic analysis, we demonstrated that MM changed the levels of proteins associated with growth factors, estrogen signaling, detoxification, and energy metabolism in the prostate of both young and old rats. These animals also showed increased levels of molecular markers of endoplasmic reticulum function and histones. We further performed

SUBMITTER: Santos SAA 

PROVIDER: S-EPMC7655221 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature