Dataset Information

Prognostic Value of the Metabolic and Volumetric Parameters of ¹¹C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Several studies have demonstrated that ¹¹C-methionine positron-emission tomography provides information on prognosis.

Purpose

We performed a systematic review and meta-analysis of the prognostic value of the metabolic and volumetric parameters of ¹¹C-methionine-PET for gliomas.

Data sources

A systematic search was performed using the following combination of keywords: "methionine," "PET," "glioma," and "prognosis."

Study selection

The inclusion criteria were the use of ¹¹C-methionine-PET as an imaging tool, studies limited to gliomas, studies including metabolic parameters (tumor-to-normal ratio) and/or volumetric parameters (metabolic tumor volume), and studies reporting survival data. The electronic search first identified 181 records, and 14 studies were selected.

Data analysis

Event-free survival and overall survival were the outcome measures of interest. The effect of the tumor-to-normal ratio and metabolic tumor volume on survival was determined by the effect size of the hazard ratio. Hazard ratios were extracted directly from each study when provided or determined by analyzing the Kaplan-Meier curves.

Data synthesis

The combined hazard ratios of the tumor-to-normal ratio for event-free survival was 1.74 with no significance and that of the tumor-to-normal ratio for overall survival was 2.02 with significance. The combined hazard ratio of the metabolic tumor volume for event-free survival was 2.72 with significance and that of the metabolic tumor volume for overall survival was 3.50 with significance.

Limitations

The studies selected were all retrospective, and there were only 4 studies involving the metabolic tumor volume.

Conclusions

The present meta-analysis of ¹¹C-methionine-PET suggests that the tumor-to-normal ratio for overall survival and the metabolic tumor volume for event-free survival and overall survival are significant prognostic factors for patients with gliomas.

SUBMITTER: Kim YI

PROVIDER: S-EPMC7655266 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Prognostic Value of the Metabolic and Volumetric Parameters of <sup>11</sup>C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis.

Kim Y-I YI Kim Y Y Lee J Y JY Jang S J SJ

AJNR. American journal of neuroradiology 20180628 9

<h4>Background</h4>Several studies have demonstrated that <sup>11</sup>C-methionine positron-emission tomography provides information on prognosis.<h4>Purpose</h4>We performed a systematic review and meta-analysis of the prognostic value of the metabolic and volumetric parameters of <sup>11</sup>C-methionine-PET for gliomas.<h4>Data sources</h4>A systematic search was performed using the following combination of keywords: "methionine," "PET," "glioma," and "prognosis."<h4>Study selection</h4>The ...[more]

PMID: 29954817

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Dataset Information

Prognostic Value of the Metabolic and Volumetric Parameters of ¹¹C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis.

Background

Purpose

Data sources

Study selection

Data analysis

Data synthesis

Limitations

Conclusions

Publications

Prognostic Value of the Metabolic and Volumetric Parameters of <sup>11</sup>C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Prognostic Value of the Metabolic and Volumetric Parameters of 11C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis.

Background

Purpose

Data sources

Study selection

Data analysis

Data synthesis

Limitations

Conclusions

Publications

Prognostic Value of the Metabolic and Volumetric Parameters of <sup>11</sup>C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Prognostic Value of the Metabolic and Volumetric Parameters of ¹¹C-Methionine Positron-Emission Tomography for Gliomas: A Systematic Review and Meta-Analysis.