Vessel Wall MRI for Targeting Biopsies of Intracranial Vasculitis.

ABSTRACT: Central nervous system vasculitides are elusive diseases that are challenging to diagnose because brain biopsies have high false-negative rates. We sought to test the ability of contrast-enhanced, high-resolution 3D vessel wall MR imaging to identify vascular inflammation and direct open biopsies of intracranial target vessels and adjacent brain parenchyma. Eight of 9 specimens revealed vascular inflammation. We conclude that vessel wall MR imaging can identify inflamed intracranial vessels, enabling precise localization of biopsy targets.

SUBMITTER: Zeiler SR 

PROVIDER: S-EPMC7655338 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature