Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma.

ABSTRACT: BACKGROUND AND PURPOSE:Diffusion-weighted imaging may aid in distinguishing aggressive chordoma from nonaggressive chordoma. This study explores the prognostic role of the apparent diffusion coefficient in chordomas. MATERIALS AND METHODS:Sixteen patients with residual or recurrent chordoma were divided postoperatively into those with an aggressive tumor, defined as a growing tumor having a doubling time of <1 year, and those with a nonaggressive tumor on follow-up MR images. The ability of the ADC to predict an aggressive tumor phenotype was investigated by receiver operating characteristic analysis. The prognostic role of ADC was assessed using a Kaplan-Meier curve with a log-rank test. RESULTS:Seven patients died during a median follow-up of 48 months (range, 4-126 months). Five of thes

SUBMITTER: Sasaki T 

PROVIDER: S-EPMC7655429 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature