A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways.

ABSTRACT:

Background

The rapid spread of SARS-CoV-2, the causative agent of Coronavirus disease 2019 (COVID-19), has been accompanied by the emergence of distinct viral clades, though their clinical significance remains unclear. Here, we aimed to investigate the phylogenetic characteristics of SARS-CoV-2 infections in Chicago, Illinois, and assess their relationship to clinical parameters.

Methods

We performed whole-genome sequencing of SARS-CoV-2 isolates collected from COVID-19 patients in Chicago in mid-March, 2020. Using these and other publicly available sequences, we performed phylogenetic, phylogeographic, and phylodynamic analyses. Patient data was assessed for correlations between demographic or clinical characteristics and virologic features.

Findings

The 88 SARS-CoV-

SUBMITTER: Lorenzo-Redondo R 

PROVIDER: S-EPMC7655495 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature