Prolonged exposure to particulate Cr(VI) is cytotoxic and genotoxic to fin whale cells.

ABSTRACT:

Background

Hexavalent chromium [Cr(VI)] is a human lung carcinogen and global marine pollutant. High Cr concentrations, resembling the ones observed in occupationally exposed workers, have been observed in fin whales (Balaenoptera physalus) in the Gulf of Maine. This outcome suggests Cr might be disrupting the health of fin whale populations. Indeed, Cr in acute (24 h) exposure does cause toxicity in fin whale cells. However, human cell culture data indicate prolonged exposures (120 h) induce a higher amount of toxicity compared to 24 h exposure due to an inhibition of homologous recombination repair. However, whether prolonged exposure causes similar outcomes in fin whale cells is unknown.

Objective

Due to the importance of assessing prolonged exposure toxicity, this study

SUBMITTER: Meaza I 

PROVIDER: S-EPMC7655514 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature