Yttrium-90 Portal Vein Radioembolization in Sprague-Dawley Rats: Dose-Dependent Imaging and Pathological Changes in Normal Liver.

ABSTRACT:

Purpose

Portal vein embolization (PVE) is an established neoadjuvant method to induce future liver remnant hypertrophy prior to surgical resection of hepatic tumors. The purpose of our study was to examine the feasibility of PVE with glass ⁹⁰Y microspheres (Y90 PVE) in Sprague-Dawley rats. We tested the hypothesis that increased doses of Y90 PVE would increase target lobe fibrosis and atrophy.

Methods

Twenty-two rats were assigned to four groups for Y90 PVE to the right median lobe: very high- (273.8 MBq; n = 2), high- (99.9 MBq; n = 10), medium- (48.1 MBq; n = 5), and low-dose (14.8 MBq; n = 5). An untreated control group included seven rats. ⁹⁰Y PET/CT of ⁹⁰Y distributions confirmed lobar targeting. MRI volumes were measured at baseline, 2-

SUBMITTER: Gordon AC 

PROVIDER: S-EPMC7655630 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature