Perturbation-induced high-frequency pulsing of nano-ESI with facile ion selection at atmospheric pressure.

ABSTRACT: Nano-ESI is a commonly used ionization technique with continually expanding analytical advantages. Here, we report a facile way for high-frequency (500-3800 Hz) pulsing of nano-ESI, providing a high flux of mobility-selected ions. The pulsing is accomplished using a relatively low-voltage modulation (80 V peak-to-peak) of an electrode placed <1 cm downstream of a nano-ESI emitter biased to a constant potential. Configuring the electrode as an ion gate enables mobility-based ion selection by scanning the modulation frequency. Our investigations indicate that the electrode modulation perturbs continuous nano-ESI, resulting in solution accumulation at the emitter tip between spray pulses. Selective transmission of ions occurs at frequencies corresponding to harmonics of a fundamental frequenc

SUBMITTER: McMahon WP 

PROVIDER: S-EPMC7655663 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature