HMGA2-mediated tumorigenesis through angiogenesis in leiomyoma.

ABSTRACT:

Objective

To study the role of HMGA2 in promoting angiogenesis in uterine leiomyoma (LM).

Design

This study involved evaluation of vessel density and angiogenic factors in leiomyomas with HMGA2 overexpression; examining angiogenic factor expression and AKT signaling in myometrial (MM) and leiomyoma cells by introducing HMGA2 overexpression in vitro; and exploring vessel formation induced by HMGA2 overexpression both in vitro and in vivo.

Setting

University research laboratory.

Patients

None.

Interventions

None.

Main outcome measures

The main outcome measures include vessel density in leiomyomas with HMGA2 (HMGA2-LM) or MED12 (MED12-LM) alteration; angiogenic factor expression in primary leiomyoma and in vitro cell line model; and vessel formation

SUBMITTER: Li Y 

PROVIDER: S-EPMC7655683 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature