Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment.

ABSTRACT: Cancer remains the second leading cause of mortality worldwide. In the course of this multistage and multifactorial disease, a set of alterations takes place, with genetic and environmental factors modulating tumorigenesis and disease progression. Metabolic alterations of tumors are well-recognized and are considered as one of the hallmarks of cancer. Cancer cells adapt their metabolic competences in order to efficiently supply their novel demands of energy to sustain cell proliferation and metastasis. At present, there is a growing interest in understanding the metabolic switch that occurs during tumorigenesis. Together with the Warburg effect and the increased glutaminolysis, lipid metabolism has emerged as essential for tumor development and progression. Indeed, several investigations h

SUBMITTER: Fernandez LP 

PROVIDER: S-EPMC7655926 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature