Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease.

ABSTRACT: Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM₃ gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerid

SUBMITTER: Huynh K 

PROVIDER: S-EPMC7655942 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature