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ABSTRACT: Background
An association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity.Aim
To evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity.Methods
Patients with morbid obesity followed in our center between January 2010 and July 2018 were included. The ones without evaluation of liver and thyroid functions were excluded. Fatty Liver Index (FLI) and BARD scores were used as predictors of hepatic steatosis and fibrosis, respectively.Results
We observed a positive association between TSH and both BARD (OR 1.14; p = 0.035) and FLI (OR 1.19; p = 0.010) in the unadjusted analysis. We found a negative association between free triiodothyronine levels and BARD (OR 0.70; p<0.01) and a positive association between free triiodothyronine levels and FLI (OR 1.48; p = 0.022). Concerning liver function, we found a positive association between total bilirubin and free thyroxine levels (β = 0.18 [0.02 to 0.35]; p = 0.033) and a negative association between total bilirubin and free triiodothyronine levels (β = -0.07 [-0.14 to -0.002]; p = 0.042).Conclusion
Higher levels of TSH and free triiodothyronine may be associated with a higher risk of NAFLD, particularly steatosis, in patients with morbid obesity.
SUBMITTER: Borges-Canha M
PROVIDER: S-EPMC7655985 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Borges-Canha Marta M Neves João Sérgio JS Mendonça Fernando F Silva Maria Manuel MM Costa Cláudia C Cabral Pedro M PM Guerreiro Vanessa V Lourenço Rita R Meira Patrícia P Salazar Daniela D Ferreira Maria João MJ Pedro Jorge J Leite Ana A Von-Hafe Madalena M Vale Catarina C Viana Sara S Sande Ana A Belo Sandra S Lau Eva E Freitas Paula P Carvalho Davide D
Frontiers in endocrinology 20201028
<h4>Background</h4>An association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity.<h4>Aim</h4>To evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity.<h4>Methods</h4>Patients with morbid obesity followed in our center between January 2010 and July 2018 were included. The ones without evaluat ...[more]