CD147 Expressed on Memory CD4⁺ T Cells Limits Th17 Responses in Patients With Rheumatoid Arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is a common autoimmune disease in which T helper-type 17 (Th17) cells have been critically involved. CD147 is a T cell activation-associated molecule and is involved in T cell development. However, it remains unclear whether CD147 participates in Th17 responses in RA patients. In this study, we demonstrated that in both the RA and healthy controls (HC) groups, CD147 expression on CD4⁺ T cells was increased in CCR6⁺ and CD161⁺ subsets, and was associated with IL-17 production. Ligation of CD147 with its monoclonal antibody (mAb) strongly inhibited Th17 responses, and knock down of CD147 expression on CD4⁺ Tm cells specifically enhanced Th17 responses, triggered by coculture with in vitro activated monocytes from HC

SUBMITTER: Miao J 

PROVIDER: S-EPMC7655988 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature