Genetic and environmental risk structure of internalizing psychopathology in youth.

ABSTRACT:

Background

Internalizing disorders (IDs), consisting of syndromes of anxiety and depression, are common, debilitating conditions often beginning early in life. Various trait-like psychological constructs are associated with IDs. Our prior analysis identified a tripartite model of Fear/Anxiety, Dysphoria, and Positive Affect among symptoms of anxiety and depression and the following constructs in youth: anxiety sensitivity, fearfulness, behavioral activation and inhibition, irritability, neuroticism, and extraversion. The current study sought to elucidate their overarching latent genetic and environmental risk structure.

Methods

The sample consisted of 768 juvenile twin subjects ages 9-14 assessed for the nine, abovementioned measures. We compared two multivariate twin models

SUBMITTER: Hettema JM 

PROVIDER: S-EPMC7656112 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature