Development and Validation of a 6-miRNA Prognostic Signature in Spinal Chordoma.

ABSTRACT:

Background

Published data have suggested a critical role for microRNA (miRNA) expression in chordoma progression. However, most of these studies focus on single miRNA and no multi-miRNA prognostic signature has been currently established for chordoma. In this study, we sought to develop and validate a 6-miRNA risk score (miRscore) model for survival prediction.

Methods

Medline, Embase, and Google scholar searches (from inception to July 20, 2018) were conducted to identify candidate miRNAs with prognostic value as per predefined criteria. Quantitative RT-PCR was used to measure miRNA levels in 114 spinal chordoma (54 in the training and 60 in the validation cohort) and 20 control specimens. Subsequently, the miRscore was built based on miRNAs data.

Results

Literature

SUBMITTER: Huang W 

PROVIDER: S-EPMC7656123 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature