Dataset Information

Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4.

ABSTRACT:

Introduction

Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals.

Methods

A total of 261 participants from the ALFA+ study underwent [¹⁸F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status.

Results

Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003).

Discussion

Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.

SUBMITTER: Sanchez-Benavides G

PROVIDER: S-EPMC7656171 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and <i>APOE</i> <i>ε4</i>.

Sánchez-Benavides Gonzalo G Salvadó Gemma G Arenaza-Urquijo Eider M EM Grau-Rivera Oriol O Suárez-Calvet Marc M Milà-Alomà Marta M González-de-Echávarri José María JM Minguillon Carolina C Crous-Bou Marta M Niñerola-Baizán Aida A Perissinotti Andrés A Gispert Juan Domingo JD Molinuevo José Luis JL

Alzheimer's & dementia (Amsterdam, Netherlands) 20201111 1

<h4>Introduction</h4>Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals.<h4>Methods</h4>A total of 261 participants from the ALFA+ study underwent [<sup>18</sup>F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used lo ...[more]

PMID: 33204815

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