Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4.

ABSTRACT:

Introduction

Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals.

Methods

A total of 261 participants from the ALFA+ study underwent [¹⁸F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status.

Results

Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant p

SUBMITTER: Sanchez-Benavides G 

PROVIDER: S-EPMC7656171 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature