Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease.

ABSTRACT:

Introduction

The molecular mechanism of neurodegeneration, including tau and neurite complexity, is an important topic in Alzheimer's disease (AD) research.

Methods

We recruited 27 amyloid-positive individuals identified through ¹¹C-Pittsburgh compound B (PiB) positron emission tomography (PET) and 31 amyloid-negative individuals with normal cognition. All participants underwent ¹¹C-PiB and ¹⁸F-THK5351 PET and magnetic resonance imaging (MRI) with neurite orientation dispersion and density imaging (NODDI) protocol. The neurite density index (NDI), orientation dispersion index (ODI), and PET images were analyzed to calculate voxel-wise correlations among the imaging modalities and correlations with cognitions.

Results

In the amyloid-pos

SUBMITTER: Sone D 

PROVIDER: S-EPMC7656172 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature