Novel domain expansion methods to improve the computational efficiency of the Chemical Master Equation solution for large biological networks.

ABSTRACT:

Background

Numerical solutions of the chemical master equation (CME) are important for understanding the stochasticity of biochemical systems. However, solving CMEs is a formidable task. This task is complicated due to the nonlinear nature of the reactions and the size of the networks which result in different realizations. Most importantly, the exponential growth of the size of the state-space, with respect to the number of different species in the system makes this a challenging assignment. When the biochemical system has a large number of variables, the CME solution becomes intractable. We introduce the intelligent state projection (ISP) method to use in the stochastic analysis of these systems. For any biochemical reaction network, it is important to capture more than one momen

SUBMITTER: Kosarwal R 

PROVIDER: S-EPMC7656229 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature