Raman spectroscopy reveals age- and sex-related differences in cortical bone from people with osteoarthritis.

ABSTRACT: Bone strength in human cortical bone is determined by the composition and structure of both the mineral and collagen matrices and influenced by factors such as age, gender, health, lifestyle and genetic factors. Age-related changes in the bone matrix are known to result in loss of mechanical strength and increased fragility. In this study we show how Raman spectroscopy, with its exquisite sensitivity to the molecular structure of bone, reveals new insights into age- and sex-related differences. Raman analysis of 18 samples of cortical hip bone obtained from people aged between 47-82 years with osteoarthritis (OA) found subtle changes in the lipid and collagen secondary structure, and the carbonate (CO₃^2-) and phosphate (PO₄^3-) mineral ratios in t

SUBMITTER: Nieuwoudt MK 

PROVIDER: S-EPMC7656243 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature