Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial.

ABSTRACT:

Importance

The benefits of vitamin D, omega-3 fatty acids, and exercise in disease prevention remain unclear.

Objective

To test whether vitamin D, omega-3s, and a strength-training exercise program, alone or in combination, improved 6 health outcomes among older adults.

Design, setting, and participants

Double-blind, placebo-controlled, 2 × 2 × 2 factorial randomized clinical trial among 2157 adults aged 70 years or older who had no major health events in the 5 years prior to enrollment and had sufficient mobility and good cognitive status. Patients were recruited between December 2012 and November 2014, and final follow-up was in November 2017.

Interventions

Participants were randomized to 3 years of intervention in 1 of the following 8 groups: 2000 IU/d of vi

SUBMITTER: Bischoff-Ferrari HA 

PROVIDER: S-EPMC7656284 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature