Variations of telencephalic development that paved the way for neocortical evolution.

ABSTRACT: Charles Darwin stated, "community in embryonic structure reveals community of descent". Thus, to understand how the neocortex emerged during mammalian evolution we need to understand the evolution of the development of the pallium, the source of the neocortex. In this article, we review the variations in the development of the pallium that enabled the production of the six-layered neocortex. We propose that an accumulation of subtle modifications from very early brain development accounted for the diversification of vertebrate pallia and the origin of the neocortex. Initially, faint differences of expression of secretable morphogens promote a wide variety in the proportions and organization of sectors of the early pallium in different vertebrates. It prompted different sectors to host vari

SUBMITTER: Garcia-Moreno F 

PROVIDER: S-EPMC7656292 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature