Postpartum pulmonary circulation in pregnant rats with monocrotaline-induced pulmonary arterial hypertension.

ABSTRACT:

Background

This is the first study to evaluate changes in postpartum pulmonary circulation in a novel pregnant rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH).

Methods

Female rats were randomly divided into two groups: the MCT-treated pregnant group, in which rats were injected with MCT (40 mg/kg) at the age of 7 weeks, and the pregnant group, in which rats were injected with the same volume of 0.9% saline at the same age. Rats from both groups were mated at the age of 9 weeks. General condition information, hemodynamic data and pulmonary tissues were collected from pregnant rats from the two groups on the 18th day after successful mating (T1) and the 1st (T2), 3rd (T3), and 7th days after delivery (T4).

Results

The MCT-treated pregnant

SUBMITTER: Jing H 

PROVIDER: S-EPMC7656411 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature