Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits.

ABSTRACT:

Background

Buprenorphine is one of the most used analgesics for postoperative pain in rabbits. The recommended dose in rabbits (0.01-0.05 mg/kg) is the same for intravenous (IV), intramuscular (IM), and subcutaneous (SC) administration, despite lack of pharmacokinetic data. Five male and five female New Zealand White rabbits (mean ± SD body weight 3.1 ± 0.3 kg) were administered 0.05 mg/kg buprenorphine by the IV, IM and SC routes and 0.1 mg/kg by the SC route, in a cross-over design with two-week wash-out periods between treatments. Blood was collected before, and up to 8 h post buprenorphine injection, for determination of serum levels by UPHLC-MS/MS.

Results

The area under the time concentration curve (AUC_0-t) was lower after SC (398 ± 155 ng/mL/min) than IM (6

SUBMITTER: Askar R 

PROVIDER: S-EPMC7656698 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature