A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.

ABSTRACT:

Background

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial mutations, due to a lack of frank neuropathology from models based on common disease genes. Recent multi-cohort studies of postmortem human brain transcriptomes have identified a set of 30 gene co-expression modules associated with LOAD, providing a molecular catalog of relevant endophenotypes.

Results

This resource enables precise gene-based alignment between new animal models and human molecular signatures of disease. Here, we describe a new resource to efficiently screen mouse models for LOAD relevance. A new NanoString nCounter® Mouse AD panel was designed to correlate key human disease processes and pathways

SUBMITTER: Preuss C 

PROVIDER: S-EPMC7656729 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature