PD-1 protein and gene expression as prognostic factors in early breast cancer.

ABSTRACT:

Background

There is a paucity of data on the prognostic value of programmed cell death protein 1 (PD-1) protein and gene expression in early breast cancer (BC) and the present study's aim was to comprehensively investigate it.

Methods

The study consisted of three parts: a correlative analysis of PD-1 protein and gene expression from an original patient cohort of 564 patients with early BC; a systematic review and trial-level meta-analysis on the association between PD-1 protein expression and disease-free survival/overall survival (OS) in early BC; and a pooled gene expression analysis from publicly available transcriptomic datasets regarding PDCD1 expression.

Results

In the study cohort, PD-1 protein, but not gene expression, was associated with improved OS (H

SUBMITTER: Matikas A 

PROVIDER: S-EPMC7656908 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature