Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors.

ABSTRACT: Innate lymphoid cells (ILCs) are a recently identified subset of leukocytes that play a central role in pathogen surveillance and resistance, modulation of immune response, and tissue repair. They are remarkably similar to CD4+ T-helper subsets in terms of function and transcription factors required for their development but are distinguished by their lack of antigen-specific receptors. Despite their similarities, the absence of a surface T-cell receptor (TCR) and presence of ILCs and precursors in adult bone marrow has led to speculation that ILCs and T cells develop separately from lineages that branch at the point of precursors within the bone marrow. Considering the common lineage markers and effector cytokine profiles shared between ILCs and T cells, it is surprising that the status o

SUBMITTER: Shin SB 

PROVIDER: S-EPMC7656916 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature