In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesis.

ABSTRACT: The emergence and continued spread of SARS-CoV-2 have resulted in a public health emergency across the globe. The lack of knowledge on the precise mechanism of viral pathogenesis is impeding medical intervention. In this study, we have taken both in silico and in vitro experimental approaches to unravel the mechanism of viral pathogenesis associated with complement and coagulation pathways. Based on the structural similarities of viral and host proteins, we initially generated a protein-protein interactome profile. Further computational analysis combined with Gene Ontology (GO) analysis and KEGG pathway analysis predicted key annotated pathways associated with viral pathogenesis. These include MAPK signaling, complement, and coagulation cascades, endocytosis, PD-L1 expression

SUBMITTER: Tiwari R 

PROVIDER: S-EPMC7657020 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature