Central amygdala mineralocorticoid receptors modulate alcohol self-administration.

ABSTRACT: The mineralocorticoid receptor (MR) is an emerging target in the field of alcohol research. The MR is a steroid receptor in the same family as the glucocorticoid receptor, with which it shares the ligand corticosterone in addition to the MR selective ligand aldosterone. Recent studies have shown correlations between central amygdala (CeA) MR expression and alcohol drinking in rats and macaques, as well as correlations between aldosterone and alcohol craving in individuals with alcohol use disorder (AUD). Additionally, our previous work demonstrated that systemic treatment with the MR antagonist spironolactone reduced alcohol self-administration and response persistence in both male and female rats. This study examined if reductions in self-administration following MR antagonist treatment w

SUBMITTER: Makhijani VH 

PROVIDER: S-EPMC7657087 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature