Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis.

ABSTRACT: Control of liver metastasis is an important issue in the treatment of colorectal cancer (CRC). MicroRNAs have been shown to be involved in the development of many cancers, but little is known about their role in the process of colorectal liver metastasis. We compared miRNA expression between primary colorectal tumors and liver metastasis to identify those involved in the process of metastasis. Cancer cells were isolated from formalin-fixed paraffin-embedded primary CRC samples and their corresponding metastatic liver tumors in six patients using laser capture microdissection, and miRNA expression was analyzed using TaqMan miRNA arrays. The most abundant miRNA in liver metastasis compared with primary tumors was miR-122. Immunohistochemical analysis revealed that the expression levels of ca

SUBMITTER: Iino I 

PROVIDER: S-EPMC7657140 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature