Clinical and prognostic implications of β1, 6-N-acetylglucosaminyltransferase V in patients with gastric cancer.

ABSTRACT: Aberrant β1, 6-N-acetylglucosaminyltransferase V (MGAT5) expression in malignant tissues has been reported to be involved in the development of various cancers and their progression, through altering N-glycan branching. We aimed to investigate the clinical and prognostic values of MGAT5 and improve the risk stratification in patients with gastric cancer. MGAT5 expression was retrospectively analyzed by immunohistochemistry in three independent sets comprising 313 patients from China with gastric adenocarcinoma. Results were assessed for association with clinical features and overall survival using Kaplan-Meier analysis. Prognostic values of MGAT5 expression and clinical outcomes were evaluated by Cox regression analysis. A molecular prognostic stratification scheme incorporating MGAT5 expr

SUBMITTER: Wang X 

PROVIDER: S-EPMC7657168 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature