Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.

ABSTRACT: Genome-wide transcriptional expression analysis is a powerful strategy for characterizing the biological activity of anticancer compounds. It is often instructive to identify gene sets involved in the activity of a given drug compound for comparison with different compounds. Currently, however, there is no comprehensive gene expression database and related application system that is; (i) specialized in anticancer agents; (ii) easy to use; and (iii) open to the public. To develop a public gene expression database of antitumor agents, we first examined gene expression profiles in human cancer cells after exposure to 35 compounds including 25 clinically used anticancer agents. Gene signatures were extracted that were classified as upregulated or downregulated after exposure to the drug. Hiera

SUBMITTER: Ushijima M 

PROVIDER: S-EPMC7657208 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature