Comparison of different modes of antibiotic delivery on gut microbiota depletion efficiency and body composition in mouse.

ABSTRACT:

Background

The use of animal models with depleted intestinal microbiota has recently increased thanks to the huge interest in the potential role of these micro-organisms in human health. In particular, depletion of gut bacteria using antibiotics has recently become popular as it represents a low cost and easy alternative to germ-free animals. Various regimens of antibiotics are used in the literature, which differ in composition, dose, length of treatment and mode of administration. In order to help investigators in choosing the most appropriate protocol for their studies, we compared here three modes of antibiotic delivery to deplete gut bacteria in C57Bl/6 mice. We delivered one of the most frequently used combination of antibiotics (a mix of ampicillin, neomycin, metronidazole a

SUBMITTER: Tirelle P 

PROVIDER: S-EPMC7657353 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature