Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women.

ABSTRACT: Trauma exposure is associated with increased inflammatory biomarkers (e.g. C-reactive protein [CRP] and cytokines), and inflammation has been shown to impact corticostriatal reward circuitry and increase anhedonia-related symptoms. We examined resting-state functional MRI in a high-trauma inner-city population of African-American women (n = 56), who reported on average five different types of trauma exposures, to investigate whether inflammation correlated with functional connectivity (FC) in corticostriatal reward circuitry in association with symptoms of anhedonia and PTSD. Plasma CRP negatively correlated with bilateral ventral striatum (VS) to ventromedial prefrontal cortex (vmPFC) FC (P < 0.01). In participants where plasma was available to also measure cytokines and their soluble rec

SUBMITTER: Mehta ND 

PROVIDER: S-EPMC7657453 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature