Induction of clpP expression by cell-wall targeting antibiotics in Streptococcus mutans.

ABSTRACT: Streptococcus mutans is one of the major bacteria of the human oral cavity that is associated with dental caries. The pathogenicity of this bacterium is attributed to its ability to rapidly respond and adapt to the ever-changing conditions of the oral cavity. The major player in this adaptive response is ClpP, an intracellular protease involved in degradation of misfolded proteins during stress responses. S. mutans encodes a single clpP gene with an upstream region uniquely containing multiple tandem repeat sequences (RSs). Here, we explored expression of clpP with respect to various stresses and report some new findings. First, we found that at sub-inhibitory concentration, certain cell-wall damaging antibiotics were able to induce clpP expression. Speci

SUBMITTER: Khara P 

PROVIDER: S-EPMC7657508 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature