High CSF thrombin concentration and activity is associated with an unfavorable outcome in patients with intracerebral hemorrhage.

ABSTRACT:

Background

The cerebral thrombin system is activated in the early stage after intracerebral hemorrhage (ICH). Expression of thrombin leads to concentration dependent secondary neuronal damage and detrimental neurological outcome. In this study we aimed to investigate the impact of thrombin concentration and activity in the cerebrospinal fluid (CSF) of patients with ICH on clinical outcome.

Methods

Patients presenting with space-occupying lobar supratentorial hemorrhage requiring extra-ventricular drainage (EVD) were included in our study. The CSF levels of thrombin, its precursor prothrombin and the Thrombin-Antithrombin complex (TAT) were measured using enzyme linked immune sorbent assays (ELISA). The oxidative stress marker Superoxide dismutase (SOD) was assessed in CSF. I

SUBMITTER: Krenzlin H 

PROVIDER: S-EPMC7657554 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature