Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series.

ABSTRACT: Viral shedding patterns and their correlations with immune responses are still poorly characterized in mild coronavirus (CoV) disease 2019 (COVID-19). We monitored shedding of viral RNA and infectious virus and characterized the immune response kinetics of the first five patients quarantined in Geneva, Switzerland. High viral loads and infectious virus shedding were observed from the respiratory tract despite mild symptoms, with isolation of infectious virus and prolonged positivity by reverse transcriptase PCR (RT-PCR) until days 7 and 19 after symptom onset, respectively. Robust innate responses characterized by increases in activated CD14⁺ CD16⁺ monocytes and cytokine responses were observed as early as 2 days after symptom onset. Cellular and humoral severe acute

SUBMITTER: Vetter P 

PROVIDER: S-EPMC7657589 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature