Elucidation of Biological Networks across Complex Diseases Using Single-Cell Omics.

ABSTRACT: Single-cell multimodal omics (scMulti-omics) technologies have made it possible to trace cellular lineages during differentiation and to identify new cell types in heterogeneous cell populations. The derived information is especially promising for computing cell-type-specific biological networks encoded in complex diseases and improving our understanding of the underlying gene regulatory mechanisms. The integration of these networks could, therefore, give rise to a heterogeneous regulatory landscape (HRL) in support of disease diagnosis and drug therapeutics. In this review, we provide an overview of this field and pay particular attention to how diverse biological networks can be inferred in a specific cell type based on integrative methods. Then, we discuss how HRL can advance our unders

SUBMITTER: Li Y 

PROVIDER: S-EPMC7657957 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature