Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents.

ABSTRACT:

Background

Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine repeatedly measured during gestation are associated with brain morphology and white matter microstructure in 518 preadolescents aged 9-12 years.

Method

Data came from 518 mother-child pairs participating in the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands. Maternal urine concentrations were determined for 6 dialkylphosphates (DAPs) including 3 dimethyl (DM) and 3 diethyl (DE) alkyl phosphate meta

SUBMITTER: van den Dries MA 

PROVIDER: S-EPMC7657967 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature