Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years.

ABSTRACT:

Background

Perfluoroalkyl substances (PFAS) are suggested to interfere with thyroid hormone during pregnancy and influence fetal neurodevelopment. Epidemiological evidence regarding behavioral difficulties in childhood associated with prenatal PFAS exposure has been inconclusive.

Objective

We evaluated the association between prenatal PFAS exposure and behavioral difficulties at 7 and 11 years, and investigated the potential mediating role of maternal thyroid hormones.

Methods

Using pooled samples in the Danish National Birth Cohort established between 1996 and 2002, we estimated the associations between concentrations of six types of PFAS in maternal plasma (median, 8 gestational weeks) and child behavioral assessments from the Strength and Difficulties Questionnaire

SUBMITTER: Luo J 

PROVIDER: S-EPMC7657987 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature