Hepatocellular carcinoma tumour volume doubling time: a systematic review and meta-analysis.

ABSTRACT:

Background

Tumour growth patterns have important implications for surveillance intervals, prognostication and treatment decisions but have not been well described for hepatocellular carcinoma (HCC). The aim of our study was to characterise HCC doubling time and identify correlates for indolent and rapid growth patterns.

Methods

We performed a systematic literature review of Medline and EMBASE databases from inception to December 2019 and national meeting abstracts from 2010 to 2018. We identified studies reporting HCC tumour growth or tumour volume doubling time (TVDT), without intervening treatment, and abstracted data to calculate TVDT and correlates of growth patterns (rapid defined as TVDT <3 months and indolent as TVDT >9 months). Pooled TVDT was calculated using a rand

SUBMITTER: Nathani P 

PROVIDER: S-EPMC7657990 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature