Exposure to DDT from indoor residual spraying and biomarkers of inflammation among reproductive-aged women from South Africa.

ABSTRACT:

Background

Evidence from animal studies suggests that DDT and DDE can adversely affect immuno-competence while human data are less conclusive. We aimed to assess the association of plasma concentrations of DDT and DDE with biomarkers of inflammation among reproductive-aged women residing in homes sprayed with DDT through Indoor Residual Spraying (IRS).

Methods

This study included 416 women from the Study of Women and Babies, South Africa (2010-2011). DDT, DDE, and biomarkers of inflammation (immunoglobulins A, G and M, interleukins 1β, 6, and 8, tumor necrosis factor-α, C-reactive protein, serum amyloid-A, intercellular adhesion molecule-1, vascular cell adhesion molecule-1) were quantified in plasma. Linear regression was used to assess associations of DDT and DDE with each

SUBMITTER: Cupul-Uicab LA 

PROVIDER: S-EPMC7658024 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature