Angiogenesis related gene expression significantly associated with the prognostic role of an urothelial bladder carcinoma.

ABSTRACT:

Background

Bladder urothelial carcinoma (BLCA) is still one of the most malignant diseases and has a dismal outcome. Angiogenesis has confirmed its critical role in the development of malignant neoplasms. In this study, we uncovered the prognostic implications of the angiogenesis-related gene panel in urothelial tumors.

Methods

The RNA-seq data and clinical records of 402 patients with BLCA were collected from the TCGA database. The panel, including 145 genes involved in angiogenesis, was retrieved from the Uniprot database and the published work. The patients with similar expressed profiles were clustered, and the differences in gene expression were compared. The correlation of gene expression and BLCA outcomes or clinical features were analyzed.

Results

There were t

SUBMITTER: Wang J 

PROVIDER: S-EPMC7658114 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature