Compositional differences of gut microbiome in matched hormone-sensitive and castration-resistant prostate cancer.

ABSTRACT:

Background

It is known that gut microbiota can regulate cancer therapies. We hypothesized that gut microbiota may interact with androgen deprivation therapy (ADT) in the process of castration-resistant prostate cancer (CRPC). Here, the differences in gut microbiota between matched hormone-sensitive prostate cancer (HSPC) and CRPC were determined before and after ADT.

Methods

We profiled the fecal microbiota in matched HSPC and CRPC from 21 patients who received ADT at our urological center using 16S rRNA gene amplicon sequencing. Differences in microbiota were determined with α/β-diversity and LefSe analysis. Functional inference of microbiota was performed with PICRUSt.

Results

The results showed that the gut microbial community in CRPC was significantly altered with

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7658119 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature